CDR Tickets

Issue Number 3027
Summary Drug combo terms with clinical trials links
Created 2009-11-18 11:07:25
Issue Type Improvement
Submitted By Beckwith, Margaret (NIH/NCI) [E]
Assigned To Englisch, Volker (NIH/NCI) [C]
Status Closed
Resolved 2010-01-28 11:03:12
Resolution Fixed
Path /home/bkline/backups/jira/ocecdr/issue.107355
Description

BZISSUE::4703
BZDATETIME::2009-11-18 11:07:25
BZCREATOR::Margaret Beckwith
BZASSIGNEE::Volker Englisch
BZQACONTACT::William Osei-Poku

We have now added a new batch of drug combination terms to the Drug Dictionary and they have links to the clinical trials in the definitions. Since the way these got removed for the previous batch was based on the fact that there is a Drug Combination Summary for the combo, we can't use that to eliminate these search strings (until all of them have DCS written). Possible solutions:
1. Hard code list of drug combo terms that shouldn't have the search strings
2. Put an attribute (or something) in the term record to indicate "Exclude clinical trial search string"
3. Other?

Comment entered 2009-12-04 18:13:06 by Englisch, Volker (NIH/NCI) [C]

BZDATETIME::2009-12-04 18:13:06
BZCOMMENTOR::Volker Englisch
BZCOMMENT::1

We had discussed last week that we should suppress the clinical search string for those terms with a SemanticType=Drug Combination.

(I have another note written that says: "Maybe add TermType=DrugCombination")

The two terms that Lakshmi had identified on BACH where
ABVE Regimen and
AC Regimen
Neither of these terms currently lists the SemanticType as Drug Combination.

I'm increasing the priority based on last weeks discussion.

Comment entered 2009-12-07 13:52:41 by Beckwith, Margaret (NIH/NCI) [E]

BZDATETIME::2009-12-07 13:52:41
BZCOMMENTOR::Margaret Beckwith
BZCOMMENT::2

Yes, that agrees with what I remember (now that you reminded me!). We didn't want to mess with Semantic Type, and we decided to add a term type to capture these.

Comment entered 2009-12-09 13:48:44 by Englisch, Volker (NIH/NCI) [C]

BZDATETIME::2009-12-09 13:48:44
BZCOMMENTOR::Volker Englisch
BZCOMMENT::3

(In reply to comment #2)
> We didn't want to mess with Semantic Type, and we decided to add a term
> type to capture these.

This means that the schema needs to be modified to add the 'Drug Combination' value to the LOV, right?

Should I go ahead and make the change to the schema and the filter on MAHLER?

Comment entered 2009-12-10 12:29:25 by Beckwith, Margaret (NIH/NCI) [E]

BZDATETIME::2009-12-10 12:29:25
BZCOMMENTOR::Margaret Beckwith
BZCOMMENT::4

I guess it would go in TermTypeName since that is where we have the legacy term DrugCombination. It doesn't really fit any of the categories well.

Comment entered 2009-12-16 16:34:16 by Englisch, Volker (NIH/NCI) [C]

BZDATETIME::2009-12-16 16:34:16
BZCOMMENTOR::Volker Englisch
BZCOMMENT::5

I've modified the schema on MAHLER
TerminologySchema.xml - R9437
and added the new TermTypeName string 'Drug Combination' and I modified the filter
CDR000134: Vendor Filter: Term - R9438
to suppress the clin. search string when this TermTypeName has been selected.

I've published the document
ABVE regimen (CDR652555)
from MAHLER and pushed it to the GatekeeperGK:
http://wwwgk.cancer.gov/Templates/drugdictionary.aspx?CdrID=652555

Please verify the changes.

Comment entered 2009-12-28 14:13:42 by Beckwith, Margaret (NIH/NCI) [E]

BZDATETIME::2009-12-28 14:13:42
BZCOMMENTOR::Margaret Beckwith
BZCOMMENT::6

Looks good to me. Ready to promote.

Comment entered 2009-12-28 16:29:52 by Englisch, Volker (NIH/NCI) [C]

BZDATETIME::2009-12-28 16:29:52
BZCOMMENTOR::Volker Englisch
BZCOMMENT::7

The schema and filter have been copied to FRANCK and BACH:
TerminologySchema.xml - R9437
CDR000134: Vendor Filter: Term - R9438

Please verify on BACH (after the next publishing event) and close this bug.

Comment entered 2010-01-14 09:49:26 by Osei-Poku, William (NIH/NCI) [C]

BZDATETIME::2010-01-14 09:49:26
BZCOMMENTOR::William Osei-Poku
BZCOMMENT::8

(In reply to comment #7)
> The schema and filter have been copied to FRANCK and BACH:
> TerminologySchema.xml - R9437
> CDR000134: Vendor Filter: Term - R9438
>
> Please verify on BACH (after the next publishing event) and close this bug.

I have added (on Bach) 'Drug Combination' TermTypeName to the two records mentioned in comment #1. I will wait for the next publishing job to verify on cancer.gov.

Comment entered 2010-01-14 15:48:35 by Englisch, Volker (NIH/NCI) [C]

BZDATETIME::2010-01-14 15:48:35
BZCOMMENTOR::Volker Englisch
BZCOMMENT::9

(In reply to comment #8)
> I will wait for the next publishing job to verify on cancer.gov.

Or we could just hot-fix these terms.

Comment entered 2010-01-15 12:20:41 by Osei-Poku, William (NIH/NCI) [C]

BZDATETIME::2010-01-15 12:20:41
BZCOMMENTOR::William Osei-Poku
BZCOMMENT::10

(In reply to comment #9)
> (In reply to comment #8)
> > I will wait for the next publishing job to verify on cancer.gov.
>
> Or we could just hot-fix these terms.

I checked Cancer.gov for the two terms and the search strings have correctly been suppressed. As discussed in the CDR meeting yesterday, CIAT will add the new value to the affected terms. I will wait for Margaret to review the changes before closing it.

Comment entered 2010-01-21 12:27:49 by Beckwith, Margaret (NIH/NCI) [E]

BZDATETIME::2010-01-21 12:27:49
BZCOMMENTOR::Margaret Beckwith
BZCOMMENT::11

It looks fine on Cancer.gov. I would like to keep the issue open until CIAT has added the Term Type Name to the rest of the list.

Comment entered 2010-01-27 15:19:34 by Osei-Poku, William (NIH/NCI) [C]

BZDATETIME::2010-01-27 15:19:34
BZCOMMENTOR::William Osei-Poku
BZCOMMENT::12

(In reply to comment #11)
> It looks fine on Cancer.gov. I would like to keep the issue open until CIAT
> has added the Term Type Name to the rest of the list.

CIAT has finished updating the records. Thanks!

Comment entered 2010-01-28 11:03:12 by Beckwith, Margaret (NIH/NCI) [E]

BZDATETIME::2010-01-28 11:03:12
BZCOMMENTOR::Margaret Beckwith
BZCOMMENT::13

I have checked these terms on Cancer.gov and they look fine. Closing issue.

Elapsed: 0:00:00.000856