The association between HRT and breast cancer risk among women with a family history of breast cancer has not been consistent; some studies suggest risk is particularly elevated among women with a family history, while others have not found evidence for an interaction between these factors.[22, 27, 28, 29, 30, 31] The increased risk of breast cancer associated with HRT use in the large meta-analysis did studies suggest risk is particularly elevated among women with a family history, while others have not found not differ significantly between subjects with and without a family history.[31] The WHI study has not reported analyses stratified on breast cancer family history